MOTS-c
Injection · coming soon
MOTS-c is a 16-amino-acid peptide made by your mitochondria, and exercise raises it. Researchers call it an exercise mimetic and study it for insulin sensitivity, blood sugar, liver health and physical capacity. Now it’s coming to SuccessRx: prescribed by a licensed provider and made by a state-licensed U.S. pharmacy.
Ordering opens soon
See what I can start todayMOTS-c isn’t available to order yet. Prices post here the day it opens.
Prescribed by licensed U.S. providers. Prepared by state-licensed U.S. pharmacies.
What’s in your plan
- An online visit and review by a licensed U.S. provider
- MOTS-c prepared for you by a state-licensed U.S. pharmacy
- Supplies and step-by-step instructions for your form
- Messaging with your care team in your patient portal
- Refills that ship on your plan’s schedule
How MOTS-c works
- MOTS-c is coded in your mitochondrial DNA and works mainly in muscle. It switches on AMPK, your cells’ energy sensor, which helps muscle take up glucose and respond to insulin. Under stress, it moves into the cell’s nucleus and turns on protective genes.
How to take it
- Prescribed as an injection under the skin or into the muscle
- Your provider sets the dose and schedule
- Licensed U.S. providers
- State-licensed U.S. pharmacies
- Tracked shipping to your door
- Injection
A licensed provider reviews every request.
A provider licensed in your state reads your health answers, decides whether MOTS-c fits you and sets your dose. Questions later go straight to the Clinical chat in your portal.
Three steps to your door.
- Answer health questions
Online, in 3–5 minutes, on your own time.
- A provider reviews them
A licensed U.S. provider decides if MOTS-c fits and sets your dose.
- It ships to you
A state-licensed U.S. pharmacy prepares it and ships it with tracking.
Discovered in 2015. Studied from mouse labs to a 27,527-person genetic study.
MOTS-c is coded in your mitochondrial DNA and works mainly in muscle. It switches on AMPK, your cells’ energy sensor, which helps muscle take up glucose and respond to insulin. Under stress, it moves into the cell’s nucleus and turns on protective genes.
- Humans · 27,527 people
People with a weaker natural variant of MOTS-c had more type 2 diabetes, mostly if they were inactive. In mice, the variant lost MOTS-c’s insulin-sensitizing effect.
Zempo et al. · Aging · 2021 - Humans · 20 people
In a 4-week placebo-controlled trial of a MOTS-c analogue in adults with obesity and fatty liver, blood sugar and the liver enzymes ALT and AST fell, with no serious side effects.
CohBar phase 1b trial · NCT03998514 · 2021 - Mice and humans
MOTS-c improved running capacity in young, middle-aged and old mice. In 10 young men, one cycling session raised MOTS-c in muscle and blood.
Reynolds et al. · Nature Communications · 2021 - Mice and cells
The discovery study: MOTS-c acted on muscle through AMPK and prevented insulin resistance from aging and a high-fat diet, and obesity from the diet.
Lee et al. · Cell Metabolism · 2015 - Mice
MOTS-c prevented and reversed diet-induced fatty liver disease, including fat buildup, inflammation and scarring.
Lu et al. · Cell Reports · 2024 - Mice and cells
In obese mice, MOTS-c lowered myostatin, a signal that breaks down muscle, and it blocked fat-induced muscle loss in cells.
Kumagai et al. · Am J Physiol Endocrinol Metab · 2021
Questions before you start
Straight answers from the SuccessRx care team.
20 mg or 60 mg?
MOTS-c comes in two vial strengths. Your provider sets your dose; the vial size mostly decides how many doses it holds.
Does MOTS-c replace exercise?
No. It’s called an exercise mimetic because it switches on some of the same signals exercise does. Exercise also raises your own MOTS-c, so keep training.
Do I need a video visit?
Not in most states. Twelve states and Washington, D.C. require a short video visit by law, and the intake tells you if yours is one of them. Everywhere else, it’s online questions only.
How does it get to me?
Once your provider prescribes, a state-licensed U.S. pharmacy prepares your order and ships it with tracking. You can follow every step in your patient portal.
Can I cancel?
Yes. Pause, cancel or move your next refill date yourself in your patient portal, under Orders & Subscriptions. No phone call needed.
Who prescribes it?
A provider licensed in your state reviews your answers and decides whether MOTS-c fits you. If it doesn’t, they’ll tell you why.
How do I reach someone?
Message the care team in your patient portal any time, or email hello@successrx.com. Medication questions go to the Clinical chat in your portal.
Find out if MOTS-c fits you.
Ordering opens soon. Prices post on this page the day MOTS-c is ready.
See what I can start todayOften compared with MOTS-c
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Important safety information
Compounded medicines are prepared by a state-licensed pharmacy for one patient on a prescription. They are not FDA-approved, and the FDA does not review them for safety, effectiveness or quality. Tell your provider about every medicine you take, and message the Clinical chat in your patient portal with any medication question.
Product images are illustrations; actual packaging may vary. Lifestyle photography is illustrative.